Filter Results
Filter Results
Filter by Offering
Advanced Synthesis Small Molecules Capsules & Health Ingredients Cell & Gene Corporate Drug Product Services Integrated Biologics Licensing Mammalian Specialized Modalities
Particle Engineering (11) Bioavailability Enhancement (9) Inhalation (8) Drug Substance (API/HPAPI) (3) Solid Form Services (1)
Formulation Development and Optimization (7) API Services (3) First-in-Human Services (2)
Micronization (16) Particle Size Reduction (8) Hot Melt Extrusion (2) Spray Dried Dispersions (1)
Webinar (on-demand) (5) White paper (4) Peer-reviewed publication (2) Podcast (1) Poster (1) Presentation (on-demand) (1) Technical/Service brief (1) Video (1)
MicronizationX
Reset Filters
   Loading...
Showing 1‐16 of 16
Webinar (on-demand)
55 min read
De-Risking Early Phase Micronization with Integrated Solid Form Selection
Achieving the right particle size for respiratory drug delivery is crucial, and jet milling is a key technique. But how do you choose the right API solid form (salt, cocrystal, or solvate) for successful micronization and high yields? This webinar o...
White paper
Unlocking the Potential of Carrier-Based Formulations: A Process Optimization Guide
Carrier-based formulations are commonly used in drug delivery systems, particularly in inhalation therapies. These formulations involve dispersing active pharmaceutical ingredients (APIs) onto carrier particles, facilitating their delivery to the lungs. ...
Video
30 min read
Small Molecule API & HPAPI Development Capacity
This video presents Lonza's capabilities, facility locations, and timelines to assist biopharma companies in identifying suitable partners for their development and manufacturing needs. Lonza is known for its expertise in particle engineering and has mult...
Webinar (on-demand)
Beyond Jet Milling: A Deep Dive into Carrier-Based Formulation and Process Optimization
This webinar will look at the requirements for pulmonary delivery via carrier-based inhaled powder formulations, and how jet milling can be used to manufacture effective and stable materials for these formulations. It will also look at how it can be integ...
Technical/Service brief
5 min read
Particle-Size Engineering Through Micronization
Stability, flowability, dissolution rate, and bioavailability (BA) are all critical performance parameters affected by particle-size distribution. As part of our integrated product development services, Lonza offers premier particle engineering capabiliti...
Webinar (on-demand)
Jet Milling: A Key Process for Manufacturing Inhaled Particles
Carrier-based formulations for dry powder inhalers are precisely designed to transport extremely small particles (1-5 µm) into the lungs. When developing a carrier-based formulation, jet milling can be used to micronize these particles. High or low ...
Podcast
Inhalation Particle Engineering with Jet Milling
Jet milling is a well-established particle engineering technique for producing micronized powders with controlled particle size distribution and increased surface area. This makes them suitable for inhalation drug delivery. However, successful implementat...
Webinar (on-demand)
From Powder to Particles with Jet Milling
This presentation will cover the principles and intricacies of the jet milling process. It will also highlight some of the challenges when micronizing for inhalation delivery, and give some possible solutions. A case study will demonstrate a reliable pro...
Presentation (on-demand)
Particle Size Control Through Micronization: Challenges and Solutions
Micronization is an important technique in drug formulation, but not all substances are simple to process. This presentation will provide insight into how micronization processes can be developed for challenging inhalation materials.
Webinar (on-demand)
How To Deal With A Difficult To Micronize Drug Substance
After giving an overview of micronization and common scale-up challenges, this on-demand webinar presents a robust process development strategy that ensures all attributes critical for quality are maintained for even the most difficult APIs.
Poster
Hierarchical Mass Transfer Analysis of Drug Particle Dissolution
Dissolution tends to be the rate-limiting step in oral delivery of poorly soluble, highly permeable solid dosage forms. Drug properties that can be rate-controlling in the dissolution process are intrinsic solubility, pKa, particle size and polydispersity...
White paper
Particle Engineering For Inhalation Drug Delivery
Inhalation-based drug products play a critical role in addressing the rising incidence of respiratory diseases around the globe. Particle engineered-based formulations are key in designing and developing effective dry powder inhaler (DPI)-based drugs. Thi...
White paper
Engineering Approaches to Respiratory Drug Delivery: Mannitol Case Study
Spray drying and jet milling are commercially viable engineering processes for the development of respirable drug products. This summary presents a case study that explores the material and performance properties of spray-dried and jet-milled mannitol for...
White paper
Particle Engineering For Respiratory Drug Delivery
Pulmonary illness rates are increasing and respiratory diseases. A critical quality attribute of inhalable powders is that they are in the 1-5 micron size range for optimum deposition in the lung. This executive summary contains (1) discussion of particle...
Peer-reviewed publication
Impact of Process Parameters on Particle Morphology and Filament Formation in Spray-Dried Eudragit L100 Polymer
In preparing amorphous solid dispersions (ASDs) to increase bioavailability, Eudragit L100 has proven a useful excipient, due to its favorable impact on ASD physical stability and dissolution performance. However, when Eudragit L100 is spray-dried, high-a...
Peer-reviewed publication
Effect of Spray-Dried Particle Morphology on Mechanical and Flow Properties of Felodipine in PVP VA Amorphous Solid Dispersions
Although amorphous solid dispersions (ASDs) successfully increase bioavailability, they can result in high tablet masses. This paper describes work to reduce the tablet mass of an ASD prepared from a low-Tg, rapidly crystallizing compound. Two polymers we...